Bovine Ecolizer

$9.50

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  • Model: 10ml Oral Syringe
  • Shipping Weight: 0.2lbs
  • 10000 Units in Stock
  • Manufactured by: Novartis Animal Health

Bovine Ecolizer®

Escherichia Coli Antibody

Equine Origin

For use in newborn calves as an aid in the prevention of colibacillosis caused by K99 piliated Escherichia coli.

Broad-spectrum protection
Contain polyclonal antibodies against E. coli,with proven protection against E. coli containing the K99 pilus (attachment) antigen.

Proven protection
Based on time-tested antiserum technology and are proven to protect calves against severe and lethal challenges of K99 E. coli

Immediate protection
Both products go to work immediately, providing supplemental antibodies to calves that are at high risk for scours. Highly susceptible calves to consider are those with unknown immunoglobulin levels, those that have survived a difficult birth and those from first-calf heifers.

Convenient and versatile packaging

 Available in single-dose presentations to reduce potential animal-to-animal transmission of disease or 100 mL, multi-dose vials for a more economical solution.

Calf scours caused by E. coli is one of the major causes of neonatal calf losses.

Newborn calves are protected against disease primarily through “passive immunity” where protective antibodies are passed from the dam to the nursing calf via colostrum. However, there are cases where this protection may not be enough.

Calves may need added scours protection in these situations:

  • Cow was not vaccinated with a calf scours vaccine
  • Scours vaccination program was incomplete or poorly timed
  • Calving difficulty
  • Twins
  • Poor mothering (heifers)
  • Calf is weak or has trouble nursing
  • Colostrum quantity or quality is poor
  • Unusually severe outbreak of scours in the herd
  • Complications of mud, wet and cold weather, or crowding

Features

Strong scours protection

  • Bovine Ecolizer helps prevent calf scours by supplementing the antibody protection a newborn calf receives from its dam
  • An oral product that gives calves direct protection against E. coli bacteria by working within the calf’s intestine, the site of infection, to prevent these bacteria from attaching

No needles

  • Available in convenient single-dose syringes for simple and sanitary dosing
  • Provides newborn calves with immediate, dependable protection against scours caused by K99 piliated E. coli

Directions For Use

Administer entire contents of syringe orally to calves less than four hours after birth. Slowly syringe toward the back of the calf’s mouth. Colostrum should be fed to each calf.

Presentation

Bovine Ecolizer + C20 is available in 12 x 20 mL single-dose syringes.

Technical disease information

Escherichia coli

Despite advances in sanitation, vaccination and antibiotics, baby calf scours caused by Escherichia coli(colibacillosis) is still a primary killer of newborn calves. The K99 pilus is a primary virulence factor found on enterotoxigenic strains of E. coli (ETEC) that are isolated from calves. The pilus is an attachment mechanism which allows the ETEC to colonize on the microvilli in the lower small intestine. Colonization and irritation interfere with absorption of fluids from the gut, producing hypermotility and diarrhea. The production of enterotoxins contributes to the diarrhea by causing hypersecretion of fluids from the intestinal cells.

Clostridium perfringens Type C

Type C enterotoxemia is caused by an intestinal overgrowth of Clostridium perfringens Type C, which produces primarily beta and some alpha exotoxins.

Clostridium perfringens Type C is widely distributed in the soil and is a common inhabitant of the intestinal tract.Calves may be found dead without previously showing symptoms. If seen, symptoms include abdominal pain, diarrhea (sometimes blood-tinged) and depression.Engorgement with milk or grain is considered a predisposing factor for enterotoxemia. It is believed that a large intake of milk may slow the digestive processes, allowing the clostridial bacteria time to multiply. In addition the enzyme trypsin, which can inactivate the beta toxin, may not be present in adequate concentrations under these circumstances.

It is usually the healthy, vigorous offspring of high-producing dams which are affected by the disease.

Postmortem lesions vary according to the predominating type of exotoxin. If alpha toxin redominates there can be extensive hemorrhage in the jejunum and ileum as well as the mesenteric and intestinal lymph nodes. There may be blood-stained contents in the lower intestine and the colon. If beta toxin predominates there can be necrosis of the jejunum and ileum and peritonitis. Petechial hemorrhages may be found on the spleen, heart, thymus and serosal surfaces.

Prevention

Preventing baby calf scours requires careful management of the cow, the environment and the calf. Ensuring good passive immunity in calves is essential and will be aided by vaccinating their dams with a product like Scour Bos®9. However, some dams such as first-calf heifers may not provide adequate calf protection through colostrum and milk antibodies. The treatment of calves with scours is costly and may be too late.

Bovine Ecolizer Is a specific antibody supplement to the colostrum to aid in the prevention of scours in calves. These antibodies, when administered orally to newborn calves, help prevent the colonization of the E. coli bacteria in the small intestine and help prevent Clostridium perfringens

Type C toxins from causing damage. The effectiveness of these products is best when administered as soon after birth as possible. Effectiveness was measured in challenge studies and is summarized in Tables 1 and 2 below.

 

Reference:

1. Data on file, Novartis Animal Health US, Inc.

2. Data on file, Novartis Animal Health US, Inc.